[Hyperkeratotic papules on the hands].

The patient was a 24-year-old black woman with no past history of interest, who was seen for asymptomatic lesions on the margins of both hands and in the creases of both palms. The lesions had progressively increased in number over a period of 2 years. In her family history, it was found that her father and 1 brother had similar lesions on the margins of the hands and feet. Physical examination revealed crateriform, polygonal, hyperkeratotic papules on the margins of both hands (Figure 1A), in the creases of both palms (Figure 1B), and on the palmar aspect of the interphalangeal joints (Figure 2A), where callous-type lesions were also present (Figure 2B). No other areas of the body were affected. Histopathology One of the papular lesions was biopsied and histopathological study revealed an area of orthokeratotic hyperkeratosis on a depressed region of epidermidis that was slightly acanthotic but otherwise normal. The underlying dermis was considered normal (Figure 3). Documento descargado de http://www.actasdermo.org el 13/04/2017. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato.